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Sex-Specific Genetics of Autism Explored in Mice – Technology Networks

Researchers have studied a genetic mutation that is a likely cause of autism spectrum disorder in girls. Female, but not male mice lacking a working copy of the…



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After reviewing a database of gene mutations in children with autism spectrum disorder (ASD), a team of Medical University of South Carolina (MUSC) researchers decided to study a specific gene mutation that likely caused ASD in a girl. They demonstrated that the mutation was damaging to the gene, and that female, but not male, mice lacking a working copy of the gene also showed ASD-associated symptoms. Better understanding the interplay between genetics and sex in ASD could set the stage for developing…

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